Celiac Disease: Know the Signs!Gluten-Free Diet - coeliac disease: and Diverticulitis 2021 Celiac Disease May Require a Gluten-Free Diet Some food grain antigens found in wheat, rye, and barley are thought to create a toxic reaction in those who suffer from celiac disease, gluten intolerance, wheat allergy, and other health problems. Studies have been inconclusive but gluten intolerance seems based on genetic makeup, especially in people of Northern European descent.