5 Tips to Decrease STRESS Without Medication 20222 Endorphins are predominantly produced in the hypothalamus and pituitary glands, although they can also be produced in other regions of the body. Endorphins are responsible for the well-known "runner's high" that occurs after prolonged, hard exercise. Meditation and yoga Yoga and meditation are well-known for their stress-relieving and relaxing properties. This could be attributed in part to the release of endorphins.